Zirconium hydroxysulphate

Endpoint summary

Description of key information

Zirconium salts have been shown to be of low acute oral toxicity with indicative LD50 > 2000 mg/kg

Further animal testing on a corrosive substance is not justified

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute oral toxicity tests were carried out on 4 groups of six male Wistar rats. Test material was administered as a suspension in corm oil by stomach tube. The LD50 doses were calculated from the tables published by Weil.

GLP compliance:

no

Remarks:

Study pre-dates the introduction of GLP

Test type:

standard acute method

Limit test:

no

Specific details on test material used for the study:

Zirconium lactate

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 g

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

Oral doses of 0.75, 1.5, 3.0 and 6.0 g/kg of body weight were given as range-finding doses.
Groups of six rats were then given graduated doses of 1.25, 2.5, 5.0 and 10.0 g/kg of zirconium lactate.

No. of animals per sex per dose:

6 male rats per dose.

Control animals:

not specified

Statistics:

The LD50 doses were calculated from the tables published by Weil

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Interpretation of results:

GHS criteria not met

Conclusions:

In a study in male Wistar rats, the oral LD50 was found to be > 10 000 mg/kg bw, the maximum dose tested.

Executive summary:

Groups of male Wistar rats were administered zirconium lactate suspended in corn oil at doses of 1.25, 2.5, 5.0 and 10.0 g/kg. The oral LD50 was found to be greater than the maximum dose tested, i.e. > 10 g/kg bw.

Reference 2

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

Data from handbook with no method data provided.

GLP compliance:

not specified

Test type:

standard acute method

Species:

rat

Route of administration:

oral: unspecified

Dose descriptor:

LD50

Remarks:

rats

Effect level:

1 688 mg/kg bw

Based on:

test mat.

Remarks:

zirconium tetrachloride

Dose descriptor:

LD50

Remarks:

mice

Effect level:

655 mg/kg bw

Based on:

test mat.

Remarks:

zirconium tetrachloride

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The LD50 for zirconium tetrachloride is reported to be 1688 mg/kg bw in rats, and 655 mg/kg bw in mice.

Executive summary:

The LD50 for zirconium tetrachloride is reported to be 1688 mg/kg bw in rats, and 655 mg/kg bw in mice.

Reference 3

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

Data from handbook with no data on method provided.

GLP compliance:

not specified

Test type:

standard acute method

Species:

rat

Dose descriptor:

LD50

Effect level:

3 500 mg/kg bw

Based on:

test mat.

Remarks:

zirconium oxychloride

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of zirconium oxychloride in rats is reported to be 3500 mg/kg bw.

Executive summary:

The LD50 of zirconium oxychloride in rats is reported to be 3500 mg/kg bw.