Registration Dossier
Registration Dossier
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EC number: 203-251-6 | CAS number: 104-91-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data taken from a review of nitro-phenols
4-Nitrophenol considered suitable for read-across potential for toxicity the oxidation form of the nitrogen is not critical for short term toxic effects.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Concise International Chemical Assessment Document 20
- Author:
- World Health Organisation
- Year:
- 2 000
- Bibliographic source:
- International Programme on Chemical Safety, Concise International Chemical Assessment Document 20
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Precise details of methods not in the review
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitrophenol
- EC Number:
- 202-811-7
- EC Name:
- 4-nitrophenol
- Cas Number:
- 100-02-7
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 4-Nitrophenol
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No details in review
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- No details in review
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- Over 4 days
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- animal: Mean
- Time point:
- 24/48/72 h
- Score:
- 6
- Reversibility:
- fully reversible
- Remarks on result:
- other: Limited information
- Irritant / corrosive response data:
- No details in review
- Other effects:
- No details in review
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Two studies are cited in the review with one causing slight irritation to rabbits and the other moderate irritation
The scoring system used is unclear, but the conclusion is that on the basis of the data presented, the substance is irritating to skin
This is consistent with the class of substances
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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