Registration Dossier
Registration Dossier
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EC number: 203-251-6 | CAS number: 104-91-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Single dose treatment
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data taken from a review of nitro-phenols
4-Nitrophenol considered suitable for read-across potential for toxicity the oxidation form of the nitrogen is not critical for short term toxic effects.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Concise International Chemical Assessment Document 20
- Author:
- World Health Organisation
- Year:
- 2 000
- Bibliographic source:
- International Programme on Chemical Safety, Concise International Chemical Assessment Document 20
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-nitrophenol
- EC Number:
- 202-811-7
- EC Name:
- 4-nitrophenol
- Cas Number:
- 100-02-7
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 4-Nitrophenol
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- 4-Nitrophenol considered suitable for read-across potential for toxicity the oxidation form of the nitrogen is not critical for short term toxic effects.
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- Dose levels not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 220 - < 620 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Range reflects a numbr of tests performed at different times
- Mortality:
- Mortality at highest treated groups to allow an LD50 to be estimated
- Clinical signs:
- other: Tachypnoea and cramps
- Gross pathology:
- Discolouration and patches on lungs reported in some studies
Any other information on results incl. tables
Although the review does not provide details, the results are based on at least three separate oral studies in the period 1970 - 1981
The conclusion of the reviewers suggest Acute Tox 4 as the classification outcome.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Although the review does not provide details, the results are based on at least three separate oral studies in the period 1970 - 1981
The conclusion of the reviewers suggest Acute Tox 4 as the classification outcome.
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