Registration Dossier
Registration Dossier
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EC number: 700-251-2 | CAS number: 72684-95-8
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2009-02-18 to 2009-04-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines for testing of chemicals. 111 Hydrolysis as a Function of pH. State Environmental Protection Administration of China. Beijing: China Environmental Science Press.2004.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: The Guidelines for the Testing of Chemicals. (HJ/T 153-2004).
Test material
- Reference substance name:
- 4-hydroxy-3,5-dimethoxybenzonitrile
- Cas Number:
- 72684-95-8
- IUPAC Name:
- 4-hydroxy-3,5-dimethoxybenzonitrile
- Test material form:
- solid
Constituent 1
Results and discussion
- Preliminary study:
- Less than 10% of hydrolysis rate was observed. So the test substance was considered hydrolytically stable under our test conditions and no further trial was needed.
Any other information on results incl. tables
Preliminary Test Results |
||||||
pH |
4.0 |
7.0 |
9.0 |
|||
C0 (mg/L) |
65.6 |
65.6 |
65.5 |
65.5 |
64.5 |
64.5 |
Ct (mg/L) |
65.5 |
65.8 |
64.5 |
63.7 |
62.5 |
62.5 |
(C0 - Ct)/ C0 × 100 (%) |
0.2 |
-0.3 |
1.5 |
2.7 |
3.1 |
3.1 |
The average rate of hydrolysis (%) |
-0.1Ps |
2.1 |
3.1 |
|||
C0 - Initial concentration Ct - 5d final concentration Ps: Negative hydrolysis rate indicates that the concentration of the substance increased. Preliminary test was performed on the test substance at each pH of 4.0, 7.0 and 9.0. |
||||||
Applicant's summary and conclusion
- Conclusions:
- Hydrolytically stable at pH 4.0, 7.0, and 9.0
- Executive summary:
A preliminary test was performed in accordance with OECD Guideline 111 at each pH of 4.0, 7.0, and 9.0. Less than 10% of hydrolysis rate was observed. Therefore, the test substance is considered hydrolytically stable under the test conditions, and no further trials were needed.
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