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EC number: 942-063-5 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.01.2014 to 25.01.2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: EU A.6.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 105
- Deviations:
- no
- Principles of method if other than guideline:
- Based on the results of preliminary tests, the n-octanol/water partition coefficient was determined via the individual solubilities of the test item in n-octanol and water using the flask method (EU Method A.6 and OECD Guideline 105).
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Siemens AG, Prozess-Sicherheit, Industriepark Höchst, B 596 & B 598, D-65926 Frankfurt am Main, Germany
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Fatty acids, coco derivs. II, reaction products with glycine, potassium salts
- EC Number:
- 942-063-5
- Molecular formula:
- R-CO-NH-CH2-COOK (Note: "R-CO-" is a fatty acid residue)
- IUPAC Name:
- Fatty acids, coco derivs. II, reaction products with glycine, potassium salts
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Ajinomoto Co., Inc., 15-1 Kyobashi 1-Chome, Chuo-Ku, Tokyo 1048315, Japan/Batch No.: 130808
- Expiration date of the lot/batch: 07.08.2016
- Purity test date: 24.09.2013
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature (10-30°C)
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:no
FORM AS APPLIED IN THE TEST (if different from that of starting material): solid
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2
- Temp.:
- 20 °C
- pH:
- 9
Applicant's summary and conclusion
- Conclusions:
- Based on the individual solubilities of the test item in n-octanol and water, the log Pow was calculated to be -2.0 at 20°C.
- Executive summary:
The n-octanol/water partition coefficient was investigated in a study conducted according to OECD Guideline 105 and EU Method A.6 (flask method) based on preliminary tests. Based on the result obtained in the frame of the water solubility determination and the result of the n-octanol solubility determined within this study via HPLC, the log Pow was calculated to be -2.0 at 20°C. The recovery experiments with standard solutions indicated a sufficient accuracy of the analytical method.
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