Registration Dossier
Registration Dossier
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EC number: 234-232-0 | CAS number: 10605-21-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Carbendazim
- EC Number:
- 234-232-0
- EC Name:
- Carbendazim
- Cas Number:
- 10605-21-7
- Molecular formula:
- C9H9N3O2
- IUPAC Name:
- carbendazim
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Weight range of 2.4 to 2.7 kg and app. 10 to 12 weeks of age prior to treatment (day 1).
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: hair from the dorso-lumbar region was removed (100 mm^2)
- Vehicle:
- water
- Amount / concentration applied:
- 0.5 g test substance was applied under a gauze pad which had been moistened with 0.5 ml distilled water to one intact site on each animal.
- Duration of treatment / exposure:
- Each treatment site was covered with elastic adhesive dressing for 4 h and the animals replaced into their cages.
- Observation period:
- Alla animals were observed daily for signs of ill health or toxicity. Examination of the treated skin was made app. 1 h after removal of the dressings, on day 2, 3 and 4.
- Number of animals:
- 3 male
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 0
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
No clinical signs of ill health or toxicity were noted. No dermal reactions upon treatment were noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Carbendazim applied once with a semi-occlusive dressing to intact rabbit skin induced no skin reactions.
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