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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25.7.2018 - 02.08.2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: gas chromatography method
Principles of method if other than guideline:
The objective of this study was to determine the Vapor pressure of the test item, polyflow 130 using Gas chromatography method.
Following equipments were used in the study: Gas Chromatograph GC-2010 plus (Shimadzu, Japan)

The solvent n-Hexane was used as diluent and as well as reference item.
A Gas Chromatography involves equilibrium between volatile solute, solvent and an inert gas used as a carrier gas. A very basic equation relating the net solute retention time “t” at Temperature “T” in a solvent is given by
tx pos
--- = ------
ts pox

where tx = retention time of unknown solute in solvent
ts = retention time of reference solute in solvent
pos =Vapor pressure of reference solute in solvent
pox = Vapor pressure of unknown solute in solvent

The method was developed using GC – FID taking the following points in to consideration.
• The test item physical state was viscous liquid resembling peanut oil.
• The boiling point of the test item was 215.2 (sourced from study No., 8032)
• The vapor pressure of any test item equals 100 kPa (1atm pressure) at its boiling point
• The vapor pressure of the test item would be less than 100kPa, since water vapor pressure matches 100kPa at 100°C
• At 25°C the water vapor pressure is around 3.17 kPa, hence for the test item the vapor pressure would be less than 3.17kPa.
The reference items mentioned, having known pressures at 25°C was sourced from standard literatures mentioned and were prepared in n-hexane solvent and injected in to gas chromatography. The retention time of the individual reference item, which is based on their vapor pressure was recorded.

The calculations were carried out using Microsoft® Excel 2010. The values were interlinked and truncated to appropriate decimals based on its significance. There will be slight deviation in the final results if calculated using calculator.
Vapor pressure conversion factor = 133.322
Vapor pressure, mmHg x 133.322 = Vapor pressure, Pa
Regression equation = Y = bX + a
where Y = Ln (P°s)
b = Slope = -7.8506
X = Ln (ts)
a = Intercept = 14.6899
GLP compliance:
yes
Type of method:
other: Gas chromatogaphy
Specific details on test material used for the study:
Identification Polyflow 130
Appearance Yellow to amber colored liquid
Chemical Name Amines, N-tallow alkyltrimethylenedi-,reaction products with epichlorohydrin
Batch No. ST-637
CAS No. 93821-29-5
Molecular weight Not available
Molecular Formula Not available
Purity (%) Not available
Manufacturing date March, 2018
Expiry date Feb, 2020
Stability The product is stable under storage at normal ambient temperature
Storage conditions Room Temperature (20 to 30ºC)
Safety precautions Aprons, masks, caps, gloves and goggles were used to ensure the health and safety of the personnel
Key result
Temp.:
25 °C
Vapour pressure:
1.3 Pa

The test item Vapor pressure was determined by gas chromatography method. The reference items were chosen such a way that the retention time covers the test item retention time. A natural logarithms data plot was constructed using ln (ts), the retention time and ln (P°s), the known vapor pressure (at 25°C) of the reference items. The regression coefficient >0.90 reveals method suitability. The regression equation was used to derive the vapor pressure of polyflow 130. The details on data generated were given inTable -1

TABLE -1 VAPOR PRESSURE OF REFERENCE ITEMS AND TEST

  ITEM

Reference items

Retention time, Minutes (ts)

Ln (ts)

*Vapor pressure (P°s)

LN (P°s)

R1

R2

Mean (ts)

mm Hg

Pa

Hexane

1.809

1.808

1.809

0.592

153.0

2.040E+04

9.92

Toluene

1.969

1.968

1.969

0.677

28.40

3.786E+03

8.24

Dimethyl phthalate

10.912

10.928

10.920

2.391

0.00308

4.106E-01

-0.89

Dibutyl phthalate

16.867

16.872

16.870

2.826

0.0000201

2.680E-03

-5.92

Chlorpyrifos

17.222

17.22

17.221

2.846

0.0000202

2.693E-03

-5.92

Tebuconazole

20.92

20.932

20.926

3.041

0.000000023

3.106E-06

-12.68

Permethrin

23.625

23.624

23.625

3.162

0.0000000518

6.906E-06

-11.88

Slope

-7.8506

Intercept

14.6899

Correlation coefficient

-0.9663

Regression coefficient

0.9338

*Data representing at 25°C were sourced from standard literatures

 

Vapor pressure of test item Replicate-1

Test item

RT (Min), tx

Ln(tx)

Vapor Pressure, Px

Polyflow 130

6.281

1.8375

Intercept(a)

Slope (b)

Ln (tx)

(b) x Ln (tx)

Ln (Px)

(Pa)

14.6899

-7.8506

1.8375

-14.4257

0.26

1.30

Vapor pressure of test item Replicate-1

Test item

RT (Min), tx

Ln(tx)

Vapor Pressure, Px

Polyflow 130

6.276

1.8367

Intercept(a)

Slope (b)

Ln (tx)

(b) x Ln (tx)

Ln (Px)

(Pa)

14.6899

-7.8506

1.8367

-14.4257

0.26

1.30

Conclusions:
The vapor pressure of the liquid test item was 1.30Pa, derived from known vapor pressure of reference items at 25°C.
Executive summary:

The test item Vapor pressure was determined by gas chromatography method. A Gas Chromatography involves equilibrium between volatile solute, solvent and an inert gas used as a carrier gas. The reference items were chosen such a way that the retention time covers the test item retention time. A natural logarithms data plot was constructed using ln (ts), the retention time and ln (P°s), the known vapor pressure (at 25°C) of the reference items. The regression coefficient >0.90 reveals method suitability. The regression equation was used to derive the vapor pressure of polyflow 130. The vapor pressure of the liquid test item was 1.30Pa

Description of key information

The vapour pressure (Polyflo130; GC): 1.30Pa at 25 °C

Key value for chemical safety assessment

Vapour pressure:
1.3 Pa
at the temperature of:
25 °C

Additional information

The test item Vapor pressure was determined by gas chromatography method.A Gas Chromatography involves equilibrium between volatile solute, solvent and an inert gas used as a carrier gas.The reference items were chosen such a way that the retention time covers the test item retention time. A natural logarithms data plot was constructed using ln (ts), the retention time and ln (P°s), the known vapor pressure (at 25°C) of the reference items. The regression coefficient >0.90 reveals method suitability. The regression equation was used to derive the vapor pressure of polyflow 130.