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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the Safety Assessment of Tocopherol, TocopherylAcetate, TocopherylLinoleate, TocopherylLinoleate/Oleate, TocopherylNicotinate, TocopherylSuccinate, DioleylTocopherylMethylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, Tocophersolan
Author:
Monice Zondlo Fiume
Year:
2002
Bibliographic source:
International Journal of Toxicology, 21 (Suppl. 3): 51-116, 2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
α-tocopherol
EC Number:
200-412-2
EC Name:
α-tocopherol
Cas Number:
59-02-9
Molecular formula:
C29H50O2
IUPAC Name:
(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
Test material form:
liquid: viscous

Test animals

Species:
rat
Details on test animals or test system and environmental conditions:
Details not provided.

Administration / exposure

Route of administration:
oral: unspecified
Details on oral exposure:
Details not provided.
Doses:
4000 mg/kg bw
Details on study design:
Details not provided.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 4 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The oral LD50 of Tocopherol was stated as > 4 g/kg for rats.