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Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Falling short of highest standards concerning aspects of protocol or reporting. Acceptable literature publication.

Data source

Reference
Reference Type:
publication
Title:
Spezifische IgE-, IgG- und IgG4-Antikörper bei isozyanatbedingtem Asthma bronchiale im Vergleich mit Kontrollpersonen und Arbeitnehmern unterschiedlicher Berufsgruppen mit Isozyanatexposition
Author:
Saak A, Lenaerts-Langanke H & Stresemann E
Year:
1996
Bibliographic source:
Zentralbl. Arbeitsmed. 46 (9): 326-337

Materials and methods

Type of study / information:
Type of experience: Human

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
MDI, diphenylmethane 4,4'-diisocyanate : casnr. 101-68-8, no more data.

Results and discussion

Any other information on results incl. tables

Specific IgE antibodies against the respective diisocyanate were: MDI, 12/46 (26.1%); TDI, 6/29 (20.7%); HDI 5/37 (13.5%). As compared to the,'normal group' (group 6), no significant differences in the titres of specific IgG and IgG4 antibodies could be found, either for the groups of test persons exposed to MDI and TDI (groups 2 + 3), or for the groups of MDI and TDI asthmatics (group 1) and the two groups of miners (groups 4 + 5). HDI-exposed atopic persons (group 2), as well as exposed non-atopic persons (group 3) and HDI-asthmatics (group 1), showed significantly higher titres of specific IgG and IgG4 antibodies as compared to the normal group (group 6). The non-specific bronchial hyperreactivity found in Group 1 was: MDI 38/46 (82.6%); TDI, 24/29 (82.8%); HDI, 37/37 (100%); controls, 11/52 (21.15%)

Applicant's summary and conclusion