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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
other: in silico tool
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
other: software tool
Title:
QSAR Toolbox
Year:
2018
Bibliographic source:
OECD

Materials and methods

Principles of method if other than guideline:
Profilers:
General Mechanistic
Protein binding potency GSH
Protein binding by OECD
Protein binding by OASIS
Protein binding potency Cys (DPRA 13%)
Protein binding potency Lys (DPRA 13%)

Endpoint Specific
Protein binding alerts for skin sensitization according to GHS
Protein Binding Potency h-CLAT
Protein binding alerts for Chromosomal aberration by OASIS
Protein binding alerts for skin sensitization by OASIS
Type of study:
other: in silico tool

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dimethyl-1,1,3,3-tetraphenyldisiloxane
EC Number:
212-361-3
EC Name:
1,3-dimethyl-1,1,3,3-tetraphenyldisiloxane
Cas Number:
807-28-3
Molecular formula:
C26H26OSi2
IUPAC Name:
1,3-dimethyl-1,1,3,3-tetraphenyldisiloxane

Results and discussion

In vitro / in chemico

Results
Key result
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No protein binding alerts were identified for the constituent 1,3-dimethyl-1,1,3,3-tetraphenyldisiloxane.