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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 October 2017 to 20 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
other: The test system utilized a high performance liquid chromatograph and a cyanopropyl reverse phase HPLC column, containing lipophilic and polar moieties.
Radiolabelling:
no
Test temperature:
30 ºC
Details on study design: HPLC method:
EQUIPMENT
- Apparatus: Agilent Technologies 1100 Series, incorporating autosampler and workstation
- Type: ultraviolet (UV) for the dead time and reference standards, and evaporative light scattering detector (ELSD) for the test item
- Type, material and dimension of analytical (guard) column: Waters XSelect HSS CN 5 μm (150 x 4.6 mm id)
- Detection system: ultraviolet (UV) for the dead time and reference standards, and evaporative light scattering detector (ELSD) for the test item
The dead time was determined by measuring the retention time of formamide (purity* 99.6%, 727 mg/L solution in mobile phase).

MOBILE PHASES
- Type: methanol: water (55:45 v/v)
- Experiments with additives carried out on separate columns: yes
- pH: 5.6
- Solutes for dissolving test and reference substances: methanol

REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, α-Endosulfan, Phenanthrene, Diclofop-methyl, and DDT

REPETITIONS
- Number of determinations: duplicate

EVALUATION
- Calculation of capacity factors k': K=(Tr-T0)/T0

- Determination of the log Koc value: Log10Koc = (log10K - A)/B
Key result
Type:
Koc
Value:
> 427 000 dimensionless
pH:
7
Temp.:
30 °C
Matrix:
cyanopropyl reverse phase HPLC column, containing lipophilic and polar moieties
Validity criteria fulfilled:
not specified
Conclusions:
The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10E5, log10 Koc >5.63.

Description of key information

Adsorption Coefficient. Greater than 4.27 x 105, log10Koc >5.63,determined using an HPLC screening method designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.

Key value for chemical safety assessment

Koc at 20 °C:
427 000

Additional information