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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 October 2017 to 20 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
< 0 g/L
Conc. based on:
test mat.
Incubation duration:
ca. 48 h
Temp.:
20 °C
pH:
>= 6 - <= 6.3
Details on results:
Actual fortified test item solution concentrations, solution observations and solution pH values are shown in the following table (Table 1):

Table 1.

Sample Number

Fortified Test Item Concentration (g/L)

Observations

Solution pH

Sample Number

1

1.0 x 10-3

A clear, colorless solution, with no visible excess, undissolved test item, however the solution demonstrated a very strong Tyndall beam, indicative of a dispersion of undissolved, emulsified test item.

6.0

1

2

5.0 x 10-4

A clear, colorless solution, with no visible excess, undissolved test item, however the solution demonstrated a moderate Tyndall beam, indicative of a dispersion of undissolved, emulsified test item.

6.1

2

3

1.0 x 10-4

A clear, colorless solution, with no visible excess, undissolved test item, however the solution demonstrated a weak Tyndall beam, indicative of a dispersion of undissolved, emulsified test item.

6.3

3

Conclusions:
The water solubility of the test item has been determined to be less than 1.0 x 10-4 g/L of solution at 20.0 ± 0.5 °C.
The water solubility of the test item was addressed visually in the absence of an available analytical method capable of evaluating aqueous solutions of test item at concentrations relevant to its solubility. To further evaluate the water solubility of the test item, calculations were performed using the specialised predictive software, WSKOWWIN, version 1.42, © 2000 US Environmental Protection Agency. The water solubility calculation performed using the experimental partition coefficient limit value resulted in a water solubility of <1.5 x 10e-7 g/L (equivalent to <0.15 ppb). When repeating the calculation using the software generated partition coefficient value, not limited by available reference items in OECD Method 117, the result indicated that the actual solubility may be as low as 2.5 x 10e-14 g/L.

Description of key information

Water Solubility. Less than 1.0 x 10-4g/L of solution at 20.0 ± 0.5 °C,determined using a visual assessment flask method designed to address the data endpoint of Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Key value for chemical safety assessment

Water solubility:
0 g/L
at the temperature of:
20 °C

Additional information