Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, chloride, hydrochloride (1:1:1)

Explosiveness

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 December 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Source and lot/batch No.of test material: Sponsor and G316507

Key result

Parameter:

sensitiveness to impact: impact energy (J)

Remarks on result:

not sensitive to impact using an impact energy of 40 J

The sample of Ceftazidime Dihydrochloride (CLP) was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).

Interpretation of results:

GHS criteria not met

Conclusions:

he sample of Ceftazidime Dihydrochloride (CLP) was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).

Reference 2

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 December 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Source and lot/batch No.of test material: Sponsor and G316507

Key result

Parameter:

sensitiveness to friction: friction load (N)

Remarks on result:

not sensitive to friction using a friction load of 360 N

Remarks:

The sample of Ceftazidime Dihydrochloride (CLP) was observed to exhibit decomposition at 360 N.

The sample of Ceftazidime Dihydrochloride (CLP) was observed to exhibit decomposition at 360 N (colour change to brown). The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).

Interpretation of results:

GHS criteria not met

Conclusions:

The sample of Ceftazidime Dihydrochloride (CLP) was observed to exhibit decomposition at 360 N (colour change to brown). The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).

Reference 3

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 December 2017 to 08 December 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Source and lot/batch No.of test material: Sponsor and G316507

Key result

Parameter:

thermal sensitivity - Koenen test: diameter of the orifice plate

Remarks on result:

not thermal sensitive if heated under defined confinement

None of the tubes fragmented during testing.

During the first test run for the 2 mm orifice tests, the tube was observed to tilt after 122 seconds and an audible pop was heard. Two burners extinguished.

For the 2nd and 3rd test, a loud popping sound was heard and all four burners extinguished after 46 and 61 seconds respectively. The third tube also tilted during testing.

Interpretation of results:

GHS criteria not met

Conclusions:

The sample did not exhibit an explosion during any of the tests. The test result is therefore considered Negative.

Description of key information

The sample of the test material was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).

The sample of the test material was observed to exhibit no reaction at 360 N. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging & Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).

The sample did not exhibit an explosion during any of the tests. The test result is therefore considered Negative.

Key value for chemical safety assessment

Explosiveness:

non explosive