Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

The potential for bioconcentration/bioaccumulation (BCF/BAF) of sucrose acetate isobutyrate (SAIB) in fish was assessed using the well-accepted QSAR model of Arnot and Gobas (2003). The model predicts BCF/BAF based solely upon regressions with the Log Kow of a substance, and with an estimate where biotransformation rate of the substance is taken into account.  BCF/BAF estimates based solely on the regression of the Log Kow value(s) for this substance suggest values that are moderate to high (BCF=267 at Log Kow 3.4 and BCF=1.2e4 at Log Kow 7).  However, when biotransformation rates are taken into account the BCF and BAF predicted values are very low, < 30 L/kg wet weight regardless of the log Kow utilized from the range of measured Log Kow values. ADME processes for SAIB are well understood for mammals including rats, human, and dog, all showing a lack of bioaccumulation potential (see Toxicokinetics, metabolism and distribution section). Together these data provide a strong weight of evidence of the low potential for bioconentration/bioaccumulation in fish and mammals.