Reaction products of diazotized mixture of aniline, toluidines and xylidines coupled with mixture of aniline, toluidines and xylidines, subsequently diazotized then coupled with 2-naphthol

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

yes

Remarks:

2 deviations which have minor to no impact on the study conclusion

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

>= 2.33 - <= 6.17

Temp.:

39.6 °C

pH:

ca. 6.5

Remarks on result:

other: the pH value is the pH of ultrapure water

Details on results:

The values of log Pow derived from individual measurements of the test item are within a range of 0.1 log unit, so within the criteria of the OECD 117 guideline.

Deviations to the study plan:

-Deviation No 1 : The Log Pow was in the range 2.33 to 6.17 so it is not in the applicability range 0 to 6 as described in the § 8 « APPLICABILITY » of the Study plan (in accordance with the OECD guideline 117).

This deviation has minor impact on the study conclusion. Indeed, the reference item 4,4’-DDT proposed by the guideline has a log Kow value of 6.5. Moreover, there is at least one reference substance with a retention time below and one after the test item retention time and the linear regression used by the method has a good coefficient of determination (0.9923).

-Deviation No 2 : The expiry date of the reference items Thymol (03.Jan.2018) and 4-chloroaniline (19.Feb.2018) was reached when the HPLC analysis was realised.

This deviation has no impact on the study conclusion. Only one peak was observed on the chromatogram for each reference item so the reference item was not altered during the storage. Moreover, no quantification is required for the test OCDE 117.

Conclusions:

The estimated Partition Coefficient (Pow) logarithm of the solvent red 24 mix was in the range 2.33 to 6.17.

Key value for chemical safety assessment

Log Kow (Log Pow):

2.33

at the temperature of:

39.6 °C