Carboxylic acids, C5-9

Toxicity to soil macroorganisms except arthropods

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to soil macroorganisms except arthropods: short-term

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation of QSAR validation insufficient for assessment (not in line with OECD recommendations)

Justification for type of information:

QSAR prediction

Qualifier:

no guideline followed

Principles of method if other than guideline:

Modelling with ECOSAR v1.00

GLP compliance:

no

Specific details on test material used for the study:

Data were estimated for all the main constituents of this UVCB substance

Analytical monitoring:

not required

Test organisms (species):

other: earthworm

Animal group:

annelids

Study type:

other: calculation

Total exposure duration:

14 d

Duration:

14 d

Dose descriptor:

LC50

Remarks:

Nonanoic acid

Effect conc.:

1 911 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other: Chemical may not be soluble enough to measure this predicted effect.

Duration:

14 d

Dose descriptor:

LC50

Remarks:

Octanoic acid

Effect conc.:

1 959 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Chemical may not be soluble enough to measure this predicted effect

Duration:

14 d

Dose descriptor:

LC50

Remarks:

Heptanoic acid

Effect conc.:

1 988 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Chemical may not be soluble enough to measure this predicted effect

Duration:

14 d

Dose descriptor:

LC50

Remarks:

Hexanoic acid

Effect conc.:

1 995 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Chemical may not be soluble enough to measure this predicted effect

Duration:

14 d

Dose descriptor:

LC50

Remarks:

Pentanoic acid

Effect conc.:

1 972 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Chemical may not be soluble enough to measure this predicted effect

Duration:

14 d

Dose descriptor:

LC50

Remarks:

Nonanolide

Effect conc.:

1 925 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

Chemical may not be soluble enough to measure this predicted effect

Validity criteria fulfilled:

not applicable

Conclusions:

The 14-d LC50 for acute toxicity to earthworms of the main constituents of the target UVCB was estimated to be from 1911 to 1995 mg/kg soil dw.

Executive summary:

The acute toxicity to earthworms was modelled with ECOSAR v1.00. The 14-d LC50 was estimated to be from 1911 and 1995 mg/kg soil dw.

Reference 2

Endpoint:

toxicity to soil macroorganisms except arthropods: short-term

Data waiving:

other justification

Justification for data waiving:

other:

Description of key information

No reliable data available 
The acute toxicity to earthworms was modelled with ECOSAR V1.00. The 14 -days LC50 was estimated to be from 1911 to 1995 mg/kg soil dw.   
    
    
    
    

The acute toxicity to earthworms was modelled with ECOSAR v1.00. The 14-d LC50 was estimated to be from 1911 and 1995 mg/kg soil dw.

Additional information

According to the REACH requirements,

"In the absence of toxicity data for soil organisms, the equilibrium partitioning method may be applied to assess the hazard to soil organisms. The choice of the appropriate tests depends on the outcome of the chemical safety assessment. In particular for substances that have a high potential to adsorb to soil or that are very persistent, the registrant shall consider long-term toxicity testing instead of short-term. These studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely. " (Annex IX & X)

Carboxylic acids, C5 -9 have no potential for adsorption to soils, no significant potential for bioaccumulation and is readily biodegradable. The results of aquatic studies clearly demonstrate that the target substance is not acutely toxic. A QSAR result also indicates that no toxic effect on soil macroorganisms is to be expected (ECOSAR). Therefore, the equilibrium partitioning method is used to assess the hazard potential to soil organisms.

The results of the chemical safety assessment indicates no need to investigate further the effects of the substance and/or relevant degradation products on sediment organisms.