Registration Dossier

Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2009-11-16 to 2010-04-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
GLP study
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
capillary method
Key result
Melting / freezing pt.:
> 2 - < 90 °C
Atm. press.:
1 atm
Decomposition:
no
Sublimation:
no
Remarks on result:
other: The viscosity of the test substance decreased throughout the whole test beginning at 2 °C. At about 90 °C the test substance was a colourless liquid of low viscosity. Due to these observations no melting point but a melting range was stated.
Conclusions:
The experimental determined melting range of the test substance is 2 °C to 90 °C.
Executive summary:

The determination of the melting temperature of the test substance was performed by the capillary method with hot block heating.

At the start of the test at 2 °C the test substance was a highly viscous colourless non-stirrable mass. The viscosity of the test substance decreased throughout the whole test beginning at 2 °C. At about 90 °C the test substance was a colourless liquid of low viscosity. Due to these observations no melting point but a melting range was stated. The experimental determined melting range of the test substance is 2 °C to 90 °C.

Endpoint:
melting point/freezing point
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
2010-04-21
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
QSAR prediction
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
not applicable
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
not applicable
Principles of method if other than guideline:
Atom/fragment contribution method using the software MPBPWIN Version v1.43, provided by U.S. Environmental Protection Agency.
GLP compliance:
yes
Type of method:
other: Software MPBPWIN Version v1.43
Key result
Melting / freezing pt.:
33.8 °C
Conclusions:
The calculated melting point of the main constituent (3-Hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde) of the test substance using a QSAR-method is 33.8 °C.
Executive summary:

The calculated melting point of the the main constituent (3-Hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde) of the test substance

using a QSAR-method is 33.8 °C.

Description of key information

Melting Temperature ( OECD 102, EU Method A.1.) The experimental determined melting range of the test substance is 2 °C to 90 °C. 

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
33.8 °C

Additional information

The determination of the melting temperature of the test substance was performed by the capillary method with hot block heating.

At the start of the test at 2 °C the test substance was a highly viscous colourless non-stirrable mass. The viscosity of the test substance decreased throughout the whole test beginning at 2 °C. At about 90 °C the test substance was a colourless liquid of low viscosity. Due to these observations no melting point but a melting range was stated. The experimental determined melting range of the test substance is 2 °C to 90 °C.

In addition a supporting study was performed using a QSAR method. The calculated melting point of the the main constituent 3-Hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde)of the test substance using a QSAR-method is 33.8 °C.