Propionaldehyde, reaction product with formaldehyde

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2009-11-16 to 2010-04-21

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

GLP study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

GLP compliance:

yes

Type of method:

capillary method

Key result

Melting / freezing pt.:

> 2 - < 90 °C

Atm. press.:

1 atm

Decomposition:

no

Sublimation:

no

Remarks on result:

other: The viscosity of the test substance decreased throughout the whole test beginning at 2 °C. At about 90 °C the test substance was a colourless liquid of low viscosity. Due to these observations no melting point but a melting range was stated.

Conclusions:

The experimental determined melting range of the test substance is 2 °C to 90 °C.

Executive summary:

The determination of the melting temperature of the test substance was performed by the capillary method with hot block heating.

At the start of the test at 2 °C the test substance was a highly viscous colourless non-stirrable mass. The viscosity of the test substance decreased throughout the whole test beginning at 2 °C. At about 90 °C the test substance was a colourless liquid of low viscosity. Due to these observations no melting point but a melting range was stated. The experimental determined melting range of the test substance is 2 °C to 90 °C.

Reference 2

Endpoint:

melting point/freezing point

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Study period:

2010-04-21

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

QSAR prediction

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

not applicable

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

not applicable

Principles of method if other than guideline:

Atom/fragment contribution method using the software MPBPWIN Version v1.43, provided by U.S. Environmental Protection Agency.

GLP compliance:

yes

Type of method:

other: Software MPBPWIN Version v1.43

Key result

Melting / freezing pt.:

33.8 °C

Conclusions:

The calculated melting point of the main constituent (3-Hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde) of the test substance using a QSAR-method is 33.8 °C.

Executive summary:

The calculated melting point of the the main constituent (3-Hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde) of the test substance

using a QSAR-method is 33.8 °C.

Description of key information

Melting Temperature ( OECD 102, EU Method A.1.) The experimental determined melting range of the test substance is 2 °C to 90 °C. 

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

33.8 °C

Additional information

The determination of the melting temperature of the test substance was performed by the capillary method with hot block heating.

At the start of the test at 2 °C the test substance was a highly viscous colourless non-stirrable mass. The viscosity of the test substance decreased throughout the whole test beginning at 2 °C. At about 90 °C the test substance was a colourless liquid of low viscosity. Due to these observations no melting point but a melting range was stated. The experimental determined melting range of the test substance is 2 °C to 90 °C.

In addition a supporting study was performed using a QSAR method. The calculated melting point of the the main constituent 3-Hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde)of the test substance using a QSAR-method is 33.8 °C.