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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
The justification for type of information is provided in attachment.

Bioaccumulation experimental study is not a data requirement in accordance with Annexes VII and VIII. BCF prediction is provided in order to support PBT/vPvB assessment under Annex XIII. Although the prediction shows some restrictions in terms of reliability, it's deemed to be adequate to suitably exclude B/vB classification.
Qualifier:
equivalent or similar to
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Key result
Type:
BCF
Value:
9 L/kg
Remarks on result:
other: Parameters such as pH value, temperature, etc. are not specified by the QSAR model.

The prediction shows some restrictions in terms of reliability. However, the QSAR model has a tool which allows to quantify the uncertainty in the prediction in order to carry out PBT/vPvB assessment under Annex XIII.

The predicted logBCF is equal to 0.95 (that is 9 L/kg).

For the threshold logBCF = 3.3 (i.e. threshold for B classification), the current compound can be associated (due to its Applicability Domain index value) to a conservative interval of 0.7 log units. On this basis, the compound can be safely classified as not bioaccumulative.

For the threshold logBCF = 3.7 (i.e. threshold for vB classification), the current compound can be associated (due to its Applicability Domain index value) to a conservative interval of 0.5 log units. On this basis, the compound can be safely classified as not very bioaccumulative.

Validity criteria fulfilled:
yes
Conclusions:
Overall, the predicted BCF (i.e. 9 L/kg) allows to exclude the B/vB classification under Annex XIII of REACH Regulation.

Description of key information

The substance has a predicted BCF of 9 L/kg.

Key value for chemical safety assessment

BCF (aquatic species):
9 L/kg ww

Additional information