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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Three-day White Leghorn chicken embryos were injected by the dropping of the chemical into the air chamber of the egg. Repeated injections were used with some of the chemicals. Care was taken to focus the drop exactly on the embryo visible under the inner shell membrane. Two days later dead embryos were scored and discarded. The remaining embryos were checked for deaths and malformations up to day 14 of the incubation, 11 d after the treatment. The median effective doses (ED50) and the median lethal doses (LD50) and the slopes of the dose-response curves were calculated for the total effect on day 14 of the incubation, at the end of the test; for total mortality on day 14; and for early deaths on day 5, 2 d after the treat- ment. When incomplete or irregular dose- response curves were obtained, the EDso was approximated on probit paper. When no approximations could be made, the maximum effective dose is given instead of the ED50 Dose-response curves were also plotted for the percentage of treated malformed embryos. The maximum percentage of malformed embryos obtained on this curve was used to indicate the relative amount of malformations caused by each chemical.
GLP compliance:
not specified
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(diethyldithiocarbamato-S,S')tellurium
EC Number:
244-121-9
EC Name:
Tetrakis(diethyldithiocarbamato-S,S')tellurium
Cas Number:
20941-65-5
Molecular formula:
C20H40N4S8Te
IUPAC Name:
N2,N2,N6,N6,N6,N6,N9,N9-octaethyl-1λ³,3,5λ³,5λ³,7,7,8λ³,10-octathia-4λ⁸-telluradispiro[3.3⁴.3⁴.3⁴]trideca-1,5,5,8-tetraene-2,6,6,9-tetramine
Test material form:
solid
Specific details on test material used for the study:
Name of the test item (as cited by publication): Tellurium-diethyldithiocarbamate

Test animals

Species:
other: chicken embryo
Strain:
other: White Leghorn
Sex:
male/female

Administration / exposure

Route of administration:
other: embryo injection
Vehicle:
acetone
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
11 days
Frequency of treatment:
Single injection
Duration of test:
14 days

Results and discussion

Effect levels

Dose descriptor:
other: ED50
Effect level:
26 other: nmol
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: malformations

Observed effects

An ED50 of 26 nmol and malformations have been observed in 53% of the embryos.

Applicant's summary and conclusion