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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June, 2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
yes (incl. certificate)
Type of method:
capillary method
Key result
Melting / freezing pt.:
>= 201.1 - <= 203.8 °C

During the measurements the test item samples were not transparent to light and it was not possible to present the results as transmission diagrams. Then the visual observations were used. In the temperature range of 90 0C to 210 0C some changes in test item appearance were observed in test capillaries. However no visible melting process was detected. Probably the decomposition of less thermostable components underwent. It was only in the range of 2010C to 2040C when one observed distinct melting process and a liquid phase became visible.

Above the temperature of about 204 0C the content of capillaries occupied the volume of 2 times greater than the test item initially used to do.

The determined chelate Fe(III)IDHA melting temperature,0C

Appearance 

Melting temperature

Temperature range of observed changes in

appearance,0C

 

Average of range

± std. dev.,0C

 

Visually determined range of melting ,0C

 

Average of range

± std. dev,0C

1

90,0 – 201,8

 

 

 

89,8 ± 0,4

to 201,1 ± 0,4

201,8 – 204,6

 

 

 

201,1 ± 0,4

to 203,8 ± 0,5

2

90,0 – 201,2

201,2 – 203,9

3

90,0 – 201,5

201,5 – 203,9

4

89,0 – 200,9

200,9 – 203,1

5

89,5 – 201,3

201,3 – 204,1

6

89,8 – 201,1

201,1 – 204,0

7

90,0 – 200,6

200,6 – 203,5

8

90,0 – 200,6

200,6 – 203,5

9

90,0 – 200,6

200,6 – 203,5

Conclusions:
The determined melting temperature of chelate Fe(III)IDHA is in the range of 201,1 ± 0,40C to 203,8 ± 0,5 0C.
Executive summary:

The study of determination of chelate Fe(III)IDHA melting temperature using device with metal block methodwas carried out in accordance with method EEC A 1:1.4.1.2.and according to principles of Good Laboratory Practice (Directive 2004/10/EC).

The determined melting temperature of chelate Fe(III)IDHA is in the range of 201,1 ± 0,40C to 203,8 ± 0,5 0C.

Description of key information

The study of determination of  chelate Fe(III)IDHA melting temperature using device with metal block method was carried out in accordance with method EEC A 1:1.4.1.2. and  according to principles of Good Laboratory Practice (Directive 2004/10/EC).
The determined melting temperature of test item is in the range of 201,1 ± 0,40C to 203,8 ± 0,5 0C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
201.1 °C

Additional information