Sulfates of potassium, sodium and calcium, byproduct from fermentation

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Read-across

Justification for type of information:

See attached document below.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

680 mg/L

Nominal / measured:

meas. (initial)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Conclusions:

Based on a worse case approach taking into account the highest toxicity to fish observed with the 3 source substances [Potassium sulfate (CAS 7778-80-5), Sodium sulfate (CAS 7757-82-6) and Calcium sulfate (CAS 7778-18-9)], the 96h-LC50 value of 680 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. According to CLP criteria, this substance  is not classified for its toxicity to fish.

Executive summary:

The results of the acute toxicity to fish are indicative of a similar very low toxicity of the 3 sulfates salts. The 96h-LC50 obtained for Potassium sulfate, Sodium sulfate and Calcium sulfate are 680 mg/L, 7960 mg/L and 1970 mg/L respectively. These extremely high values demonstrate the lack of adverse effects of the 3 source substances to fish. No acute toxicity study to fish is available for the registered substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. However taking into account the data available on the three sulfate salts, the registered substance is not considered to be hazardous for fish.  Based on a worse case approach, the lowest 96h-LC50 obtained with the 3 sulfate salts, namely 680 mg/L, is attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation” as representative of its acute toxicity to fish.  According to CLP criteria, this substance  is not classified for its toxicity to fish.

Description of key information

Based on a worse case approach taking into account the highest toxicity to fish observed with the 3 source substances [Potassium sulfate (CAS 7778-80-5), Sodium sulfate (CAS 7757-82-6) and Calcium sulfate (CAS 7778-18-9)], the 96h-LC50 value of 680 mg/L was attributed to the target substance "Sulfates of potassium, sodium and calcium, by-product from fermentation”. According to CLP criteria, this substance  is not classified for its toxicity to fish.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

680 mg/L

Additional information

The results of the acute toxicity to fish are indicative of a similar very low toxicity of the 3 sulfates salts. The 96h-LC50 obtained for Potassium sulfate, Sodium sulfate and Calcium sulfate are 680 mg/L, 7960 mg/L and 1970 mg/L respectively. These extremely high values demonstrate the lack of adverse effects of the 3 source substances to fish. No acute toxicity study to fish is available for the registered substance “Sulfates of potassium, sodium and calcium, by-product from fermentation”. However taking into account the data available on the three sulfate salts, the registered substance is not considered to be hazardous for fish.  Based on a worse case approach, the lowest 96h-LC50 obtained with the 3 sulfate salts, namely 680 mg/L, is attributed to the target substance “Sulfates of potassium, sodium and calcium, by-product from fermentation” as representative of its acute toxicity to fish.  According to CLP criteria, this substance  is not classified for its toxicity to fish.