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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Remarks:
repeat insult test (Buehler)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Source reference not found, but is cited in several handbooks

Data source

Reference
Reference Type:
publication
Title:
Sensitising properties of indium, palladium and vanadium
Author:
Roshchin et al
Year:
1982
Bibliographic source:
Gig. Tr Prof. Zabol 5 - 8 (1982)

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: Buehler repeat exposure
Version / remarks:
Buehler repeat exposure
Principles of method if other than guideline:
Also references 'ear swelling' test, but no details of method in the review documents
GLP compliance:
no
Type of study:
Buehler test
Justification for non-LLNA method:
Historical study that provides a positive response

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Precise form of vanadium sulphate not specified

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Described as 'albino' guinea pigs

Results and discussion

Positive control results:
Non specified

In vivo (non-LLNA)

Results
Reading:
other: Not specified
Group:
test group
Dose level:
3% concentration
No. with + reactions:
80
Total no. in group:
80
Clinical observations:
Not specified
Remarks on result:
positive indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Conclusions:
Insufficient data to sub-categorise the classification.
The review document also references ear-swelling test on vanadium sulphate as being positive