Registration Dossier

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Version / remarks:
Titration method
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Batch number of test material: C-06-3661

Results and discussion

Dissociating properties:
yes
Dissosciation constant
No.:
#1
pKa:
< 0.1
Temp.:
20 °C
Remarks on result:
not determinable because of methodological limitations

Any other information on results incl. tables

The precise pKa was not possible to determine, but the production grade material showed dissociation

It is noted that solublity in water is greatly reduced at ca pH 4

Applicant's summary and conclusion

Conclusions:
The precise pKa was not possible to determine, but the production grade material showed dissociation
It is noted that solublity in water is greatly reduced at ca pH 4