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Administrative data

Endpoint:
long-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Automatic calculation with MeCLas Tool
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: software
Title:
MECLAS (Metals Classification Tool, version V5.2) classification for Slimes and sludges, electrolytic tin refining
Author:
ARCHE Consulting
Year:
2018
Bibliographic source:
MECLAS webpage: www.meclas.eu
Report date:
2018

Materials and methods

Principles of method if other than guideline:
Aquatic toxicity of the UVCB substance was determined by classifying based on Mixture rules from EU CLP ( tier 1= summation of classified components or Tier 2 = additivity of soluble components to derive Hazard class) and back calculation to the corresponding EC10/NOEC range

Test material

Constituent 1
Chemical structure
Reference substance name:
Tin
EC Number:
231-141-8
EC Name:
Tin
Cas Number:
7440-31-5
Molecular formula:
Sn
IUPAC Name:
tin
Constituent 2
Chemical structure
Reference substance name:
Silver
EC Number:
231-131-3
EC Name:
Silver
Cas Number:
7440-22-4
Molecular formula:
Ag
IUPAC Name:
Silver
Constituent 3
Chemical structure
Reference substance name:
Antimony
EC Number:
231-146-5
EC Name:
Antimony
Cas Number:
7440-36-0
Molecular formula:
Sb
IUPAC Name:
antimony(3+)
Constituent 4
Chemical structure
Reference substance name:
Fluorine
EC Number:
231-954-8
EC Name:
Fluorine
Cas Number:
7782-41-4
Molecular formula:
F2
IUPAC Name:
fluorine
Constituent 5
Chemical structure
Reference substance name:
Lead
EC Number:
231-100-4
EC Name:
Lead
Cas Number:
7439-92-1
Molecular formula:
Pb
IUPAC Name:
lead
Constituent 6
Chemical structure
Reference substance name:
Arsenic
EC Number:
231-148-6
EC Name:
Arsenic
Cas Number:
7440-38-2
Molecular formula:
As
IUPAC Name:
arsenic
Constituent 7
Chemical structure
Reference substance name:
Nickel
EC Number:
231-111-4
EC Name:
Nickel
Cas Number:
7440-02-0
Molecular formula:
Ni
IUPAC Name:
nickel(2+)
Constituent 8
Chemical structure
Reference substance name:
Copper
EC Number:
231-159-6
EC Name:
Copper
Cas Number:
7440-50-8
Molecular formula:
Cu
IUPAC Name:
copper
Test material form:
solid: particulate/powder

Results and discussion

Effect concentrations
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
<= 0.1 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
other: most sensitive species
Details on results:
The substance is classified as chronic cat 1 to environment resulting in a EC10/NOEC < 0.01 mg/L (rapidly degradable UVCB) and < 0.1 mg/L (non-rapidly degradable UVCB). EC10/NOEC < 0.1 mg/L was selected since this covers both rapidly and non rapidly degradable UVCBs.

Any other information on results incl. tables

According to MeClas, the substance is classified as chronic 1 to environment.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Good quality estimate of the EC10/NOEC of the UVCB substance.
The substance is classified as chronic cat 1 to environment resulting in a EC10/NOEC <= 0.1 mg/L.
Executive summary:

The study provided a conservative estimate of the effect concentration, derived on basis of the classification outcome (mixture toxicity rules) from a reasonable worst-case sample of the substance using mineralogical information from the representative sample. 

 

Validity of the model used:

1. Defined endpoint: the endpoint is a REACH compliant defined endpoint

2. Unambiguous algorithm: EU CLP guidance based summation formula to determine classification, followed by back-calculation to related hazard criteria

3. Applicability domain: applicable to classify complex metal containing materials. 

4. Mechanistic interpretation - metal species: the tool translates the elemental composition into a mineralogical composition relevant for classification.

 

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