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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 February - 9 April 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
not specified
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
- Batch n°: ZR027180PUG231
- Analytical purity: 99.3%
- Expiration date: 9 November 2006
- Storage condition: at room temperature, 10 to 30°C
Key result
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Examination of the DSC thermograms indicates that a maximum test temperature of 120°C would be practical in the vapour pressure tests in order to ensure that the sample remained solid. Tests were conducted between 110 and 120°C. The DSC thermograms recorded before and after completion of the vapour pressure test showed no degradation had occurred. From the regressions, the mean vapour pressures were calculated to be as following:

 Test  1  2
 Extrapolated result at 25°C (Pa)  8.08 x 10-15  1.79 x 10-13
 Extrapolated result at 20°C (Pa)  1.54 x 10-15  4.22 x 10-14


The observed vapour pressures were low, even at the elevated temperatures used and the vapour pressure-temperature relationship is not necessarily linear over a wide temperature range, therefore, the result extrapolations to environmentally-relevant temperatures (20 and 25°C) may only be regarded as approximations. However, it may be concluded that the resultant vapour pressure is "less than 10-12Pa" at such temperatures. The assessment by DSC following the vapour pressure test showed that the second endotherm (associated with boiling) was largely absent when compared to the profile of the starting material. This change was considered due to the loss of volatiles which occurred during the exposure of the sample at elevated temperatures, and was not indicative of any significant change in the test substance integrity.

  

 

Conclusions:
The Knudsen Effusion method was applied for the determination of the vapour pressure of the test substance.
The vapour pressure of the test item was <10^(-12) Pa at 20°C and 25°C.

Description of key information

Based on a key study (K1, Bates, 2002) the vapour pressure of the test substance according to OECD guideline 104 and EC method A.4 using the Knudsen Effusion technique was determined to be <10-12 Pa at 20°C and 25°C.

Key value for chemical safety assessment

Additional information

The vapour pressure of the test item is determined to be <10-12Pa at 20 and 25°C.