Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals
- Author:
- Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K
- Year:
- 1 988
- Bibliographic source:
- Environ Mol Mutagen. 1988;11 Suppl 12:1-157
Materials and methods
Test guideline
- Guideline:
- other: Information not available from the abstract
- GLP compliance:
- not specified
- Remarks:
- Information not available from the abstract
- Type of assay:
- other: Salmonella mutagenicity test
Test material
- Reference substance name:
- Myristic acid
- EC Number:
- 208-875-2
- EC Name:
- Myristic acid
- Cas Number:
- 544-63-8
- Molecular formula:
- C14H28O2
- IUPAC Name:
- Tetradecanoic acid
- Test material form:
- solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium
- Details on test system and experimental conditions:
- A preincubation protocol was used. All tests were performed in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters.
Results and discussion
Test results
- Key result
- Species / strain:
- other: Salmonella typhimurium
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Result of Salmonella mutagenicity test on tetradecanoic acid : negative.
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