Titanium 2-hydroxy-1,2,3-propanetricarboxylate (2:5)

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the physicochemical properties of the substance indicate that it can be expected to have a low potential for adsorption

the study does not need to be conducted because the substance and its relevant degradation products decompose rapidly

Justification for type of information:

The organic component is miscible in water and readily biodegrades.
Titanium salts exist in nature, but have very poor ion exchange capacity with sedioments and clays; instead, insoluble and inert oxides will persist.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 days

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Taken from peer reviewed publication.
Not all method details were reported, but sufficient data to confirm outcome

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)

GLP compliance:

not specified

Oxygen conditions:

aerobic

Inoculum or test system:

activated sludge (adaptation not specified)

Duration of test (contact time):

28 d

Initial conc.:

ca. 10 mg/L

Based on:

not specified

Parameter followed for biodegradation estimation:

CO2 evolution

Reference substance:

other: Not specified

Key result

Parameter:

% degradation (CO2 evolution)

Value:

ca. 97

Sampling time:

28 d

Details on results:

Rate of degradation not reported and 10-day window not assessed.

Validity criteria fulfilled:

not specified

Interpretation of results:

readily biodegradable, but failing 10-day window

Conclusions:

It is possible that the 10-day window is attained, but not specified.

Cross-reference 2

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Quality control assessment for manufacture in water, resultig in stable clear solution at ca 55% w/w in water (550 g/l)

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

Direct observation in water - similar to screening stage of shake-flask method

GLP compliance:

not specified

Type of method:

flask method

Key result

Water solubility:

> 550 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

ca. 1

Details on results:

Attempts to removed water lead to increased viscosity and cloudy mixturne. The loss ov clarity may be due to formation of degradation products such as hydroxides and oxides of titanium.

Conclusions:

The substance is hightly soluble. It is supplied commercially as a solution in water at 550 g/L and is never isolated from water.

Executive summary:

The substance is hightly soluble. It is supplied commercially as a solution in water at 550 g/L and is never isolated from water.