Registration Dossier
Registration Dossier
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EC number: 430-050-2 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral, other
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- A mixture of: N,N'-ethane-1,2-diylbis(decanamide); 12-hydroxy-N-[2-[1-oxydecyl)amino]ethyl]octadecanamide; N,N'-ethane-1,2-diylbis(12-hydroxyoctadecanamide)
- EC Number:
- 430-050-2
- EC Name:
- A mixture of: N,N'-ethane-1,2-diylbis(decanamide); 12-hydroxy-N-[2-[1-oxydecyl)amino]ethyl]octadecanamide; N,N'-ethane-1,2-diylbis(12-hydroxyoctadecanamide)
- Molecular formula:
- C90H180N6O9
- IUPAC Name:
- 12-hydroxy-N-[2-(12-hydroxyoctadecanamido)ethyl]octadecanamide; N-(2-decanamidoethyl)-12-hydroxyoctadecanamide; N-(2-decanamidoethyl)decanamide
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- corn oil
- Details on oral exposure:
- Method of administration:Gavage
- Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/dayMale: 5 animals at 15 mg/kg bw/dayMale: 5 animals at 150 mg/kg bw/dayMale: 5 animals at 1000 mg/kg bw/dayFemale: 5 animals at 0 mg/kg bw/dayFemale: 5 animals at 15 mg/kg bw/dayFemale: 5 animals at 150 mg/kg bw/dayFemale: 5 animals at 1000 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:NoneLaboratory findings:Decreased bodyweight in females only at 1000 mg/kg/day andtransient effects in females at 150 mg/kg/day.Effects in organs:None
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 150 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOEL
- Effect level:
- 15 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
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