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EC number: 430-050-2 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the ECOSAR Class (Amides) and the Neutral Organic Structure Analysis Relationship (baseline toxicity).
- GLP compliance:
- no
- Specific details on test material used for the study:
- CAS Number: 123-26-2SMILES : CCCCCCC(CCCCCCCCCCC(=O)NCCNC(=O)CCCCCCCCCCC(CCCCCC)O)OCHEM : 12-hydroxy-N-[2-(12-hydroxyoctadecanoylamino)ethyl]octadecanamideMOL FOR: C38 H76 N2 O4MOL WT : 625.04
- Analytical monitoring:
- not required
- Test type:
- other: Calculation
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The lowest calculated EC50 to Green Algae for the test material is 9.61E-6 mg/L.
- Executive summary:
The short-term toxicity to green algae is calculated by ECOSAR v1.11. Lowest EC50 value for green algae, 96 h, is 9.61E-6 mg/L derived by calculation from ECOSAR class Amides. The calculated EC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for green algae is 7.79E-5 mg/L. The estimated water solubility of the test substance is 2.409E-8 mg/L. Hence, the chemical may not be soluble enough to measure this predicted effect.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the ECOSAR Class (Amides) and the Neutral Organic Structure Analysis Relationship (baseline toxicity).
- GLP compliance:
- no
- Specific details on test material used for the study:
- CAS Number: 146781-64-8SMILES : CCCCCCCCCC(=O)NCCNC(=O)CCCCCCCCCCC(CCCCCC)OCHEM : N-[2-(decanoylamino)ethyl]-12-hydroxyoctadecanamideMOL FOR: C30 H60 N2 O3MOL WT : 496.82
- Analytical monitoring:
- not required
- Test type:
- other: Calculation
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The lowest calculated EC50 to Green Algae for the test material is 4.18E-4 mg/L.
- Executive summary:
The short-term toxicity to green algae is calculated by ECOSAR v1.11. Lowest EC50 value for green algae, 96 h, is 4.18E-4 mg/L derived by calculation from ECOSAR class Amides. The calculated EC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for green algae is 0.005 mg/L. The estimated water solubility of the test substance is 4.019E-5 mg/L. Hence, the chemical may not be soluble enough to measure this predicted effect.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the ECOSAR Class (Amides) and the Neutral Organic Structure Analysis Relationship (baseline toxicity).
- GLP compliance:
- no
- Specific details on test material used for the study:
- CAS Number: 51139-08-3SMILES : CCCCCCCCCC(=O)NCCNC(=O)CCCCCCCCCCHEM : N-[2-(decanoylamino)ethyl]decanamideMOL FOR: C22 H44 N2 O2MOL WT : 368.61
- Analytical monitoring:
- not required
- Test type:
- other: Calculation
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.009 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The lowest calculated EC50 to Green Algae for the test material is 0.009 mg/L.
- Executive summary:
The short-term toxicity to green algae is calculated by ECOSAR v1.11. Lowest EC50 value for green algae, 96 h, is 0.009 mg/L derived by calculation from ECOSAR class Amides. The calculated EC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for green algae is 0.179 mg/L.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V, C3.
- GLP compliance:
- yes
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: Tween 80. Used at 100mg/l.
- Test organisms (species):
- Chlorella vulgaris
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- 9.69 mg CaCO3/L
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 25.6 mg/L
- Basis for effect:
- growth rate
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 201 (1984)
- GLP compliance:
- yes
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: see comments
- Test organisms (species):
- other: Chlorella vulgaris CCAP 211/12
- Limit test:
- no
- Total exposure duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 1 000 mg/L
- Remarks on result:
- other: No analysis of test solutions conducted since solubility is less than the analytical limit of detection (1 mg/l)
Referenceopen allclose all
Description of key information
The experimental studies on the toxicity to aquatic algae and cyanobacteria report an ErC50 (48 h) of < 1 and an EL50 > 1000 mg/l, respectively, in both cases owing to the water solubility of the substance being lower than the limit of detection.
In addition, the toxicity to aquatic algae and cyanobacteria calculated by ECOSAR v1.11 is provided for each of the three components of the amide mixture. The ECOSAR predictions shall provide an overview on the impact of the components on the endpoint.
The predicted toxicity of the components is highest for 12-hydroxy-N-[2-(12-hydroxyoctadecanoylamino)ethyl]octadecanamide (CAS 123-26-2) with an EC50 of 9.61E-6 mg/L. Hence, this component provides the most conservative value to estimate toxicity of the substance.
Nevertheless, the EPA recommends that empirical measures should be preferentially considered. Therefore, the toxicity could not be estimated because of limited solubility.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
