Registration Dossier
Registration Dossier
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EC number: 482-280-8 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 April 2018 - 24 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 2.79 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 4.4
- Conclusions:
- The water solubility of the test item has been determined to be 2.79 g/L of solution at 20.0 ±0.5 °C.
- Executive summary:
The water solubility of the test item was determined using the flask method designed to be compatible with EC Method A.6 and OECD Method 105. Preliminary results showed that the the test item would dissolve to at least 1 g/L. Definitive test results showed that the water solubility of the test item was 2.79 g/L of solution at 20.0 ±0.5 °C.
Reference
The preliminary estimate of the water solubility at 20.0 ±0.5 °C was 2.04 g/L. The solution had a pH of 5.6.
Following the preliminary results, the shake flask method was used in the definitive test to determine the water solubility of the test item.
Table 1: Results of Definitive Test
Sample Number |
Time shaken at~30°C (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
2.74 |
4.4 |
2 |
48 |
2.79 |
4.4 |
3 |
72 |
2.83 |
4.4 |
Overall concentration: 2.79 g/L at 20.0 ± 0.5°C
Description of key information
The water solubility of the test item has been determined to be 2.79 g/L of solution at 20.0 ±0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 2.79 g/L
- at the temperature of:
- 20 °C
Additional information
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