Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 472-110-0 | CAS number: 71868-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-11-29 - 2018-12-03 (experimental phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- 99.96 - 101.44 °C
- Atm. press.:
- 990 - 1 003.5 hPa
- Decomposition:
- yes
- Decomp. temp.:
- 285
- Conclusions:
- - melting range (at 990.0 - 1003.5 hPa): 100.0 - 101.4 °C
- melting point (at 990.0 - 1003.5 hPa): 100.7 °C (mean value) - Executive summary:
The test item 2-Hydroxy-1-[4-(4-(2-hydroxy-2-methylpropionyl)phenoxy)phenyl]-2-methylpropan-1-one has a melting range of 100.0 – 101.4 °C as determined by differential scanning calorimetry and capillary method [according to EU Method A.1. and OECD Test Guideline 102].
Reference
During the heating phase a distinct endothermic effect was observed in the temperature range of 100 – 110 °C, which can be assigned to the melting of the test item. As the onset temperatures in both tests do deviate by less than 0.5 K from their mean value of 100.7 °C, a melting range of 100.0 - 101.4°C is given instead of a melting point.
A second endothermic effect was detected in the temperature range of 340 – 430 °C, which could not be clearly assigned to the boiling of the test item. Thus, the capillary method was performed.
Table: Results of the DSC-measurements
Sample weight / mg |
Onset of effect / °C |
Range of effect / °C |
Weight loss / mg |
Atmospheric pressure / hPa |
12.66 |
101.44 - |
100 – 110 (endo) |
10.01 |
990.0 |
12.97 |
99.96 - |
100 – 110 (endo) |
10.24 |
1003.5 |
Capillary Method
For verification of the result for the melting temperaturethe test item was additionally tested three times according to the capillary method. In the three tests, the test item melted at an average temperature of 100.8 °C.
The molten test item was subject to a second test series according to the capillary method. Upon heating of the test item it changed its colour from transparent to yellow at approx. 285 °C and gas evolution was visible. At a temperature of approx. 310 °C the test item turned orange-brownish and evolution of gas continued. At a temperature of approx. 375 °C the test item turned dark brown and evolution of gas continued. At a temperature of 400 °C the test item turned black and foamed. At a temperature of 400 °C the test was ended.
The measurement carried out according to the capillary method showed that the second endothermic effect observed in the DSC measurements can be assigned to decomposition of the test item with concomitant gas evolution. Due to this result, no boiling point can be assigned to the test item.
Description of key information
The melting point of the test substance was determined by differential scanning calorimetry according to OECD Guideline 102 and EU Method A.1 (Schiewer, 2019).
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 100.7 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.