Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-770-8
CAS number: 110-46-3
was induced on THP-1 cells byISOAMYL NITRITE. According to this
cytotoxic profile, CV75 value of 160 µg/mL could be determined.However,
no cytotoxicity was observed for the two highest concentrations tested.In
the activation tests, therefore, the doses-range was chosen between 7.81
and 1000 µg/mLto
cover a cytotoxic profile until 50% of dead cells.
reproducible "increase" of the CD54/CD86 expression compared with the
negative control for at least three and two dose-levels respectively of ISOAMYL
a dose-response relationship was noticed for CD54/CD86 markers with an
increase of 2.37 to 12.15 and 1.68 to 2.69 fold of expression compared
to the negative control, respectively.
these results, the test item “ISOAMYL
anin vitrosensitizing potential with a Minimum Induction
Threshold (MIT) of 85 µg/mL under the conditions used during this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again