Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
28 December 2017 - 11 January 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Physical appearance: off-white to beige powder
- Test item storage: at room temperature

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
198.2 °C
Decomposition:
yes
Decomp. temp.:
> 225 °C
Remarks on result:
other:
Remarks:
(471.4 K)

Any other information on results incl. tables

Two experiments were performed to investigate the melting and boiling behaviour of the substance.

DSC EXPERIMENT 1

An endothermic peak was observed between 175°C and 225°C followed by an exothermic effect starting at 255°C (see the illustration below). The extrapolated onset temperature of the first peak was 198.159°C. The endothermic effect was most likely caused by melting of the test item. The exothermic effect wasprobably caused by reaction and/or decomposition of the test item.

After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test item. 

 

DSC EXPERIMENT 2

In order to investigate the melting peak, in Experiment 2 heating was stopped directly after the melting effect.  The extrapolated onset temperature was 198.322°C. After the experiment, an off-white molten residue remained in the sample container (original colour: off-white). It demonstrated that melting was the reason for the endothermic effect.

 

DATA HANDLING

The melting temperature was determined as the mean melting temperature of Experiment 1 and Experiment 2.

Applicant's summary and conclusion

Conclusions:
The melting temperature of the substance was determined to be 198.2°C.
Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 198.2°C.

Reaction and/or decomposition of the substance was observed at temperatures > 225°C.