3-bromo-5-fluoro-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 June 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

ISO 13320:2009

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

other: Chilworth Technology Ltd SOP No. 417

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

3-bromo-5-fluoro-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

Cas Number:

1417421-99-8

Molecular formula:

C14H10BrFN2O2S

IUPAC Name:

3-bromo-5-fluoro-1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

- Batch n°: I16FD3006
- Expiration date: 16 June 2018
- Purity: 100.1% (based on HPLC)
- Storage condition of test material: At room temperature

Results and discussion

Mass median aerodynamic diameter:

532 µm

Geometric standard deviation:

>= 2.104 - <= 2.185

Particle size

Particle size 1

Percentile:

D10

Mean:

116 µm

St. dev.:

3.33

Remarks on result:

other: Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

Particle size 2

Key result

Percentile:

D50

Mean:

405 µm

St. dev.:

7.92

Remarks on result:

other: Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

Particle size 3

Percentile:

D90

Mean:

773 µm

St. dev.:

25

Remarks on result:

other: Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.

Any other information on results incl. tables

Visual Microscope Analysis

(1) Standard visual observation: sample observed to be a polydispersed, gritty, free flowing off-white powder

(2) Observation using 3.2 objective lens: particles appeared to be irregular shaped crystals (smallest +/- 10 µm and largest +/- 1280 µm).

(3) Observation using 40 objective lens: sample was observed to be made up of single crystalline particles.

Solubility and Dispersability Test

The sample proved to be insoluble and well dispersed in silicone oil. Therefore,silicone oilwas used as the disperant.

Laser Diffraction Particle Size Analysis

Using the identified parameters, the particle size was analysed over the range 0.01 µm to 3500 µm.

The average Volume weighted Mean was 428 µm and the mode was 506 µm. The Coefficient of Variation for d50 was <3%; d10 and d90 were <5%. Thus the repeatability of the characteristic particles in the size distribution was within the acceptable limits according to the ISO 13320-1 test standard.

Applicant's summary and conclusion

Conclusions:

Observation using the 3.2 objective lens showed irregular shaped crystals between approximately 10 µm and 1280 µm.
The particle size distribution of T003685 determined by the laser diffraction method led to the conclusion that the average volume weighted mean based on 5 runs was 428 µm and the Mass Median Aerodynamic Diameter (MMAD) based on 5 runs was 532 µm, whereas the average D10, D50 and the D90 were determined to be 116 µm, 405 µm and 773 µm, respectively.