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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 07 March to 23 August
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
yes
Remarks:
see Details on methods
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
yes
Remarks:
see Details on methods
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: AL01
- Expiration date of the lot/batch: 10.09.2019
- Purity test date: not available

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: refrigerated (2 to 8°C)
- Stability under test conditions: not available
- Solubility and stability of the test substance in the solvent/vehicle: not applicable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not applicable

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: none
- Preliminary purification step (if any): none
- Final dilution of a dissolved solid, stock liquid or gel: not applicable
- Final preparation of a solid: not applicable

OTHER SPECIFICS: none
Analytical method:
other: modified gravimetric
Key result
Type:
log Pow
Partition coefficient:
< -0.07
Temp.:
25 °C
Remarks on result:
other: pH not determined, see attached explanation

Test solutions concentrations and amounts

 

Water

n-Octanol

Test solution

Initial weight (mg)

Final residue (mg)

Concen. (mg/L)

Number of mg in water

Residue (mg)

Concen. (mg/L)

Number of mg in octanol

1A

72.3298

38.02

760.40

54.75

17.58

244.18

17.58

1B

72.3298

38.63

772.60

55.63

16.70

231.98

16.70

2A

48.2198

15.83

211.07

20.26

27.96

582.45

27.96

2B

48.2198

22.96

306.13

29.39

18.83

392.31

18.83

3A

12.0550

1.56

41.60

2.00

N/A

N/A

N/A

3B

12.0550

5.07

135.20

6.49

5.57

57.97

5.57

N/A: Test 3A omitted from final calculation

Conclusions:
In the shake flask method conducted according to OECD test guideline 107 and to GLP, the LogPow value for Alfalfa, ext. was determined at < - 0.07 at 25 ± 0.5 °C.
Executive summary:

A shake flask test, conducted according to OECD test guideline 107 and to GLP, was performed to determine the Partition coefficient of Alfalfa, ext. The LogPowvalue was determined at < - 0.07 at 25 ± 0.5°C.

Description of key information

LogPow: < - 0.07 at 25 ± 0.5°C.

Key value for chemical safety assessment

Additional information

A shake flask test, conducted according to OECD test guideline 107 and to GLP, was performed to determine the Partition coefficient of Alfalfa, ext. The LogPowvalue was determined at < - 0.07 at 25 ± 0.5°C.