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Toxicological information

Toxic effects on livestock and pets

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The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the document should be considered a draft.

Ingestion of MDI based glues has demonstrated no intrinsic toxic effects, but formation of a solid polyurea mass may lead to gastric obstruction.  The mass may be removed by surgery and rapid complete recovery expected.