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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

A static test with zebrafish (OECD 203) indicated no mortality at 1000 mg/L after 96 hour.

Key value for chemical safety assessment

LC50 for freshwater fish:
1 000 mg/L

Additional information

The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. Two short-term aquatic toxicity studies are available for fish for polymeric MDI (CAS 9016-87-9). In a study with Oryzias latipes (Nakata, 1982), no acute toxicity was observed after 96h exposure to 3000 mg/L (semi-static). ). The Nichi-Nou-Sei B2735 (1965) protocol was followed, which is similar to OECD 203. A static test with Danio rerio (OECD 203) gave no mortality at 1000 mg/L, which was the highest concentration tested (Caspers, 1986). This value may be considered for the derivation of a PNECaqua. A third fish study with Danio rerio is available, but lacks some critical information. Hence it is classified as unreliable. The 24h-EC50 was determined to be > 500 mg/L. Based on the justification in the category approach of methylenediphenyl diisocyanates (MDI), it is assumed that all MDI analogues included in the category have a similar fish toxicity.