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Type of information:
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Principles of method if other than guideline:
No guideline is applicable. A computational method was employed.


Molecular Formula: C20H42N2O1

Molecular weight: 326.57

--------------------------- HYDROWIN v2.00 Results ---------------------------

Hydrolyzable Function detected: Amides


With the exception of a few halogenated acetamides, most amides hydrolyze to acids extremely slowly at 25 °C and pH 7 with half-lives measured in centuries. Electronegative groups on carbon or nitrogen greatly accelerate base catalyzed hydrolysis, but alkyl groups on nitrogen retard both acid and base catalyzed processes. No neutral hydrolysis is evident (Mabey and Mill, 1978). Selected amides half-lives include:

Half-Live (in years at 25 °C, pH 7)

Acetamide                                   3950

Chloroacetamide                         1.46

Dichloroacetamide                      0.73

Trichloroacetamide                     0.23

N-Methylacetamide                   38000

Extremely low hydrolysis is to be expected for the substance. Half lives in the order of years can be estimated.
Executive summary:

An attempt was made to calculate the hydrolysis of the substance by using the software HYDROWIN (V2.00). However, only a message was obtained that most amides hydrolyse to acids extremely slowly at 25 °C and pH 7 with half lives measured in centuries. Therefore it is concluded that the substance shows an extremely slow hydrolysis.

Description of key information

not required, since the substance is readily biodegradable

in addition, no hydrolysis expected (calculation based on structure)

Key value for chemical safety assessment

Additional information

The stability (hydrolysis) of C16 Alkylamidopropyltrimethylammonium Chloride was calculated using EPIWIN, HYDROWIN v2.00. Hydrolysis is not to be expected under environmental conditions: the calculated hydrolysis half-life time (t1/2) was found to be >1 year.