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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20141218 - 20150521 (experimental period)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study
Qualifier:
according to
Guideline:
other: ASTM no. E 1148-2, Method A2
Deviations:
yes
Remarks:
Turbidity was measured with the extinction method.
GLP compliance:
yes
Type of method:
other: Turbidity measurement
Key result
Water solubility:
203 mg/L
Conc. based on:
test mat.
Temp.:
20.1 °C
Remarks on result:
other: The pH-value of the test solution was not measured.

Turbidity of the Test Itemat Different Concentrations (Preliminary Testing)

Concentration
[g/L]

0.5

1.0

2.0

5.0

10

20

Turbidity
[NTU]

0

1

4

18

30

55

The water solubility, corresponding to the critical micelle concentration, was determined by measuring the turbidity (light extinction at a wavelength of 620 nm) of the test item at different concentrations.

Turbidity for 1 -Propanaminium, N,N,N-trimethyl-3 -[(1 -oxohexadecyl)amino]-, chloride at different concentrations

Concentration [g/L]

Number of Measurement

1-Propanaminium, N,N,N-trimethyl-3-[(1-oxohexadecyl)amino]-, chloride

Extinction (620 nm)

Mean

0.0

1

-0.001

0.000

2

0.001

3

0.000

0.1

1

0.000

0.000

2

0.000

3

0.000

0.5

1

0.003

0.003

2

0.003

3

0.003

1.0

1

0.005

0.005

2

0.005

3

0.005

1.5

1

0.010

0.010

2

0.010

3

0.011

2.0

1

0.014

0.016

2

0.014

3

0.020

2.5

1

0.018

0.018

2

0.018

3

0.018

3.01

1

0.018

0.018

2

0.019

3

0.018

3.02

1

0.021

0.022

1) = outlier confirmed by F test; values not taken into account

2) = re-analysed in duplicate

Conclusions:
The water solubility corresponding to the critical micelle concentration of 1-Propanaminium, N,N,N-trimethyl-3-[(1-oxohexadecyl)amino]-, chloride was determined to be 203 mg/L at 20.1 °C.
Executive summary:

The water solubility of the substance was determined according to ASTM no. E 1148 -2, Method A2 by measurement of the critical micelle concentration (CMC) using the turbidimetric method. The turbidity was addressed by measurement of the light extinction at a wavelength of 620 nm.

The water solubility, corresponding to the CMC of the substance was determined to be 203 mg at 20.1 °C.

Description of key information

water solubility (critical micelle concentration): 203 mg/L at 20.1°C (ASTM no. E 1148-2, Method A2, turbidity method); RL1; GLP

Key value for chemical safety assessment

Water solubility:
203 mg/L
at the temperature of:
20.1 °C

Additional information

The water solubility of C16 Alkylamidopropyltrimethylammonium Chloride was determined according to ASTM no. E 1148 -2, Method A2 by measurement of the critical micelle concentration (CMC) using the turbidimetric method. The turbidity was addressed by measurement of the light extinction at a wavelength of 620 nm.

The water solubility, corresponding to the CMC of the substance was determined to be 203 mg at 20.1 °C.