3-[2-({[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}amino)pyridin-3-yl]prop-2-yn-1-ol

Guidance on Safe Use

First-aid measures

Inhalation

After inhalation move to fresh air. If shortness of breath occurs, support respiration and consult a physician.

Bring patient immediately to fresh air. If breathing is heavily give oxygen; if necessary respirate artificially. Call physician.

Consult a physician if irritating symptoms develop and persist.

Skin Contact

Remove contaminated clothing. Rinse contaminated skin immediately with plenty of water and soap and seek medical advice.

Eye Contact

Immediately rinse eyes thoroughly with running water as long as possible (approx. 15 min). Take injured quickly to factory medical center or call an ambulance (code word: eye accident).

Ingestion

Do not induce vomiting. In case of consciousness wash mouth with water and let drink some ofwater. Seek medical advice. Keep patient at rest. If swallowed, seek medical advice immediately and show this container or label.

Fire-fighting measures

Suitable Extinguishing Media

Water spray or fog, foam, dry chemical powder, CO2, dry sand

Unsuitable Extinguishing Media

No restrictions

Special hazards arising from the substance or mixture

Dangerous Combustion Products

carbon oxides

nitrogen oxides

sulfur oxides

Hydrofluoric acid (hydrogen fluoride)

Advice for firefighters

Protective equipment for firefighters

Wear self-contained breathing apparatus and fire protective suite.

Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal precautions

Avoid contact with skin, eyes and clothing.

Environmental precautions

Do not release into the environment.

Methods and material for containment and cleaning up

Transfer large quantities into a container, rinse the rest with plenty of water. Consult experts for decontamination.

Handling and storage

Precautions for safe handling

Storage and Handling Precautions

Open handling without suitable personal protective equipment must be avoided. Keep container tightly closed in a dry, cool and well-ventilated place. Ensure efficient exhaust ventilation when using this product

Conditions for safe storage, including any incompatibilities

Technical measures/ Precautions

Handle product only in closed system or provide appropriate exhaust ventilation at machinery.

Preventive Precautions

(fire/explosion)

Take precautionary measures against static discharges. Avoid formation of dust. Keep away from sources of ignition. Observe the usual precautionary measures required for chemicals with dust explosive properties (Observe national regulations).

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally hazardous
substance, solid, n.o.s.
(Contains: Pyridine derivative)

Chemical name:

QAW039-C6

Language:

English

Special provisions / remarks

Special provisions:

Special Provision(s):
274,335,375,601
Limited Quantities: 5 kg
Excepted Quantities: max.
quantity per: inner packaging
30g/30ml - outer packaging
1kg/1L
ADR Tank Tankcode:
SGAV,LGBV
Tunnel Code: -
Hazard Identification Number
(Orange Panel Number): 90

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally hazardous
substance, solid, n.o.s.
(Contains: Pyridine derivative)

Chemical name:

QAW039-C6

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

3077

Shipping information

Proper shipping name and description:

Environmentally hazardous
substance, solid, n.o.s.
(Contains: Pyridine derivative)

Chemical name:

QAW039-C6

Remarks

SpecialProvisions

Exposure controls / personal protection

Industrial Hygiene

The personal protective measure may be adapted appropriately when working in closed systems or under laboratory conditions.

Regular cleaning of equipment, work area and clothing.

Open handling at operator intervention points with local exhaust ventilation (e.g. downflow booths).

Internal working procedures available to personnel covering personal hygiene, standard cleaning, waste disposal and maintenance.

Personnel instructed and trained, regular refresher training established.

Double wardrobe must be available.

Open Handling Respiration:

If the Breathing Zone sampling results exceed the established occupational exposure limit (OEL) or the minimum concentration defined by the occupational hazard band, use respiratory protection with sufficient protection factor to ensure exposure is below the exposure limit. Unless the exposure results indicate the requirement for an air supplied device, use HEPA filters for powders or aerosols and

cartridge or canister filters for vapors and gases.

Eye : Safety glasses (EN166)

Hand : Normal length chemical-mechanical resistant gloves (EN374/EN388)

Glove Material : Nitrile

Breakthrough time: 240 min

Thickness: 0.4 mm

Additional protection : working clothes (EN 340)

These values are derived from experiments, literature and information from the glove manufacturer.

They can also be derived from similar materials. In daily work please be aware that the using time depends on several

factors and can be shorter than the oficially tested permeation time.

Stability and reactivity

Reactivity

Reaction products with water

None known

Chemical stability

Hydrolysis : no data available

Possibility of hazardous reactions

Materials to avoid

strong acids

strong bases

Conditions to avoid

Stable at normal conditions

Hazardous decomposition products

None, when used and handled as intended.

Disposal considerations

Waste treatment methods

Disposal Requirements Incineration in an approved, controlled furnace with combustion gas scrubbing and emission gas control.

Container Disposal

For disposal local regulation is binding.