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Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental starting date: 31 July 2016 Experimental completion date: 12 October 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxy-4-(hydroxymethyl)phenol
EC Number:
674-192-5
Cas Number:
4912-58-7
Molecular formula:
C9H12O3
IUPAC Name:
2-ethoxy-4-(hydroxymethyl)phenol
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Information as provided by the Sponsor. The Certificate of Analysis provided by the Sponsor is presented as.

Identification: EVA
Common name: ETHYLVANILLYL ALCOHOL, White Vanilla
CAS Number: 4912-58-7
CAS Name: Benzenemethanol, 3-ethoxy-4-hydroxy-
Chemical Name: 2- Ethoxy-4-(hydroxymethyl)phenol
Appearance/Physical state: Pale yellow powder
Batch: 4K0001
Purity: 100%
Expiry date: 31 December 2017
Storage conditions: Room temperature in the dark

Results and discussion

Melting / freezing pointopen allclose all
Key result
Melting / freezing pt.:
ca. 76.4 °C
Decomposition:
no
Sublimation:
no
Remarks on result:
other:
Remarks:
+/- 0.5 °C
Key result
Melting / freezing pt.:
ca. 349.5 K
Decomposition:
no
Sublimation:
no
Remarks on result:
other:
Remarks:
+/- 0.5 K

Any other information on results incl. tables

The thermograms and thermographic data for determinations 1 and 2 are shown in the attached document (please see attached background material) and following table.

Thermographic Data

Thermal Event

Interpretation

Temperature

Determination 1

Determination 2

oC

K

oC

K

Sharp endotherm

Melting point

76.30

349.45

76.46

349.61

Mean melting temperature: 76.4 ± 0.5 °C (349.5 ± 0.5 K)

Applicant's summary and conclusion

Conclusions:
The melting point of the test item has been determined to be 76.4 ± 0.5 °C (349.5 ± 0.5 K).
Executive summary:

The determination was carried out by differential scanning calorimetry, using a procedure designed to be compatible with Method A.1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 102 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Conclusion

The melting point of the test item has been determined to be 76.4 ± 0.5 °C (349.5 ± 0.5 K).