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EC number: 600-581-6
CAS number: 1045809-53-7
The study was performed to assess the acute oral toxicity of the test
item in the Wistar strain rat.
Following a sighting test at a dose level of 2000 mg/kg, an additional
four fasted female animals were given a single oral dose of test item,
as a solution in dimethyl sulfoxide, at a dose level of 2000 mg/kg body
weight. Clinical signs and body weight development were monitored during
the study. All animals were subjected to gross necropsy.
Mortality. There were no deaths.
Clinical Observations. Signs of hunched posture and lethargy were noted
during the day of dosing in the initial treated animal. No other
clinical observations were noted
Body Weight. All animals showed expected gains in body weight over the
observation period except for two females who showed an expected gain in
body weight during the first week but a body weight loss during the
Necropsy. No abnormalities were noted at necropsy.
The acute oral median lethal dose (LD50) of the test item in
the female Wistar strain rat was estimated to be in the range of 300 -
2000 mg/kg body weight (Globally Harmonized Classification System -
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