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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Scientific opinion on Flavouring Group Evaluation 25, Revision 3 (FGE.25Rev3): Aliphatic hydrocarbons from chemical group 31
Author:
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and
Processing Aids (CEF)
Year:
2015
Bibliographic source:
EFSA Journal 2015;13(4):4069

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Reliable safety assessment of the European Food and Safety Authority (EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF))
GLP compliance:
not specified
Remarks:
publication
Test type:
other: not stated

Test material

Constituent 1
Chemical structure
Reference substance name:
Pin-2(3)-ene
EC Number:
201-291-9
EC Name:
Pin-2(3)-ene
Cas Number:
80-56-8
Molecular formula:
C10H16
IUPAC Name:
2,6,6-trimethylbicyclo[3.1.1]hept-2-ene

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 700 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 of alpha-pinene was estimated in male and female rats. Since the LD50 was found to be 3700 mg/kg body weight it can be assumed that alpha-pinene is of low acute oral toxicity.
Executive summary:

The acute oral LD50 of alpha-pinene was estimated in male and female rats. Since the LD50 was found to be 3700 mg/kg body weight it can be assumed that alpha-pinene is of low acute oral toxicity.