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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Start date of the experimental work: 1 February 2018 and completion date of the experimental work: 8 May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
18 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
3.4
Remarks on result:
other: (mean of three runs)

Preliminary estimation

 Mass of sample (mg) Volumne of water in which sample dissolves (ml) Estimated solubiluty (g/L)  Analysis method  
 2000 100  10 -50  Shake Flask 

Estimated Water Solubility (g.L-1): 10 - 50

Mobile phase Gradient settings

 Time (min) % Mobile Phase A  % Mobile Phase B 
 0.0  90  10
 6.0  90  10
 7.0  50  50
 9.0  50  50
 10.0  90  10
 15.0  90  10

Calibration data:

 Concentration (g/L) Peak area 1  Peak area 2  Mean Peak area 
 0.0472  1499063 1496174  1497618.5 
 0.0944  2919891 2920076  2919983.5 
 0.1416  4279997 4281428  4280712.5 
 0.1888  5605109 5609889  5607499 
 0.236 6845265   6843556 68444410.5 
 0.2832  8055611 8035502  8045556.5 
          m=27748037.2276 C=281987.6667 r2=0.9990

Analytical detraminations:

 Flask N° Dilution facteur  pH  Peak Area 1    Peak Area 2  Mean concentration (g/L)
 1  100  3.41  5340001  5338591  18.226
 2  100  3.4  5288377  5256350  17.985
 3  100  3.4  5249295  5250196  17.903

Mean water solubility (g/L): 18.0 (mean of three runs)

Conclusions:
The test is conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A6 and OECD Test Guideline 105.
The test is conducted to determine the saturation concentration of the substance in water at a given temperature.
The water solubility of the test item was found to be 18 g/L. at 20°C.(FLASK METHOD and mean of three runs)

Description of key information

The water solubility of the test item was found to be 18 g/L. at 20°C. (FLASK METHOD)

Key value for chemical safety assessment

Water solubility:
18 g/L
at the temperature of:
20 °C

Additional information