1,4-Dioxaspiro[4.5]decane, 8-[4-(4-methylphenyl)-3-cyclohexen-1-yl]-

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2003-03-31 to 2003-05-21

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - HPLC Method)

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

> 5.7

Temp.:

25 °C

Remarks on result:

other: pH: Not relevant

Reference substance	I.Inj. tR in min	2. Inj. tR in min	3. Inj. tR in min	mean tR in min	k	logk	log Pow
Acetophenone	1.50	1.50	1.50	1.500	0.3473	-0.4593	1.7
Methylbenzoate	1.77	1.77	1.77	1.770	0.5898	-0.2293	2.1
Phenylbenzoate	2.70	2.70	2.70	2.700	1.4251	0.1539	3.6
Biphenyl	4.24	4.24	4.24	4.240	2.8084	0.4485	4.0
Phenanthrene	6.54	6.54	6.55	6.543	4.8772	0.6882	4.5
Triphenylamine	9.01	9.00	9.01	9.007	7.0898	0.8506	5.7
Substance for determination of t0
Formamide	1.12	1.11	1.11	1.113

Regression equation : log k = a + b * log Pow Parameter: a = - 0.9755, b = 0.3382, r = 0.982

 

	1.Inj.tR in min	2. Inj. tR in min	3. Inj. tR in min	mean tR in min	k	logk	log Pow
test item	38.80	38.85	38.93	38.860	33.904	1.5303	7.41

The retention time of the test item is outside of the calibration range. The extrapolation of the partition coefficient to a value outside the calibration range is not recommended. Thus, the partition coefficient of the test item at 20 °C can be estimated to be higher than the value of the reference item Triphenylamine: log Pow > 5.7.

Conclusions:

The log Pow was found to be > 5.7 at 25 °C.

Executive summary:

A study was conducted according to OECD Guideline 117 using the HPLC method. The retention time of the test item is outside of the calibration range. The extrapolation of the partition coefficient to a value outside the calibration range is not recommended. Thus, the partition coefficient of the test item at 25 °C can be estimated to be higher than the value of the reference item Triphenylamine: log P_OW > 5.7.

Description of key information

The log Pow value of the test item was determined to be > 5.7 (reference 4.7-1).

Key value for chemical safety assessment

Additional information

A study was conducted according to OECD Guideline 117 using the HPLC method. The retention time of the test item is outside of the calibration range. The extrapolation of the partition coefficient to a value outside the calibration range is not recommended. Thus, the partition coefficient of the test item at 25 °C can be estimated to be higher than the value of the reference item Triphenylamine: log Pow > 5.7.