Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
ca. -3
Temp.:
20 °C
pH:
ca. 2.9
Details on results:
Due to instability of the test item, the LogPow was calculated using the individual sturation solubilities of the test item in water (cs = 190 g/L at 20^C, pH 2.9) and n-octanol (209 mg/L).
The solubilities were determined according to the flask method.
The calculated log Pow using KOWWIN is -4.

Applicant's summary and conclusion

Conclusions:
The log Pow is approx. -3.