Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 807-935-0 | CAS number: 1244733-77-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloropropan-2-yl bis(2-chloropropyl) phosphate; bis(1-chloropropan-2-yl) 2-chloropropyl phosphate; tris(1-chloropropan-2-yl) phosphate; tris(2-chloropropyl) phosphate
- EC Number:
- 807-935-0
- Cas Number:
- 1244733-77-4
- Molecular formula:
- C9H18Cl3O4P
- IUPAC Name:
- 1-chloropropan-2-yl bis(2-chloropropyl) phosphate; bis(1-chloropropan-2-yl) 2-chloropropyl phosphate; tris(1-chloropropan-2-yl) phosphate; tris(2-chloropropyl) phosphate
- Test material form:
- liquid
- Details on test material:
- Tris chloroisopropyl phosphate
Purity: 97.85% including all isomers
name: tris-chloroisopropylphosphate
manufacturer: Bayer AG (now LANXESS)
sample no: 002871/1989
content: 97.85% analytical date 8 Aug 1990
expiry date: 13 Dec 1991
appearance: clear liquid
storage: room temperature
MW: 327.6
Molecular formula:C9H18Cl3O4P
CAS no: 13674-84-5
intended use: industrial chemical
Constituent 1
- Specific details on test material used for the study:
- IUCLID4 Test substance: other TS
TS-Freetext:
Tris chloroisopropyl phosphate purity 97.85% including all
isomers as per 1.1 - 1.4.
- Name of test material (as cited in study report): Tris-chlorisopropylphosphat
- Molecular formula (if other than submission substance): C9H18Cl3O4P
- Molecular weight (if other than submission substance): 327.6
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: colourless clear liquid
- Analytical purity: 97.85%
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: 002871/1989 of 13.12.1989 production process sample
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions: guarenteed for test period
- Storage condition of test material: room temperature in dark
- Other: pH 3.7
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Interfauna UK Ltd, Huntingdon
- Age at study initiation: not given
- Weight at study initiation: 3.6-3.7 kg
- Housing:individually in stainless steel or plastic cages
- Diet (e.g. ad libitum): Standard diet Ssniff K 4 100-120 g/day
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period:at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+-3C
- Humidity (%): apprx 50%
- Air changes (per hr): 10 per hour
- Photoperiod (hrs dark / hrs light):12 hours light/dark cycle
IN-LIFE DATES: From:8-January-1991 To:15 January 1991
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: treated animals served also as control (one eye TCPP, the other remained untreated and served as control)
- Amount / concentration applied:
- 100 µl TCPP in one eye.
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- A volume of 0.1 ml of the test material was instilled into the conjunctival sac of one eye of each of three rabbits. The other eye remained untreated and served as control. The treated eyes were rinsed with saline 24 hours post-treatment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- L14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- L14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- L14 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- L25 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- M5 Female
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- There were no signs of irritation in any of the treated eyes at any of the observation times of 24, 48 and 72 hours. One animal had evidence of aqueous humour discharge at 48 hours, but this did not persist.
Any other information on results incl. tables
Test for irritant effect on the eye (expos.24hrs):
| Animal No.+Body weight | Tissue | Signs | Draize grades | |||||||
| M5, female (3,7 kg) | 1h | 24h | 48h | 72h | 7d | 14d | 21d | Irritation index | ||
| cornea | o | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
| a | 0 | 0 | 0 | 0 | 0 | - | - | |||
| fluorescein | i | - | 0 | - | - | - | - | - | ||
| a | - | 0 | - | - | - | - | - | |||
| iris | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
| conjunctivae | r | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
| s | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
| aqueous humour | 0 | 0 | 0 | 0 | 0 | - | - | |||
| discharge | 1 | 0 | 0 | 0 | 0 | - | - | |||
| L25, female(3,6 kg) | cornea | o | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 |
| a | 0 | 0 | 0 | 0 | 0 | - | - | |||
| fluorescein | i | - | 0 | - | - | - | - | - | ||
| a | - | 0 | - | - | - | - | - | |||
| iris | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
| conjunctivae | r | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
| s | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
| aqueous humour | 0 | 0 | 0 | 0 | 0 | - | - | |||
| discharge | 0 | 0 | 0 | 0 | 0 | - | - | |||
| 1 | 0 | 2 | 0 | 0 | - | - | ||||
| L14, female(3,7 kg) | cornea | o | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 |
| a | 0 | 0 | 0 | 0 | 0 | - | - | |||
| fluorescein | i | - | 0 | - | - | - | - | - | ||
| a | - | 0 | - | - | - | - | - | |||
| iris | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
| conjunctivae | r | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | |
| s | 0 | 0 | 0 | 0 | 0 | - | - | 0,0 | ||
| aqueous humour | 0 | 0 | 0 | 0 | 0 | - | - | |||
| discharge | 1 | 0 | 0 | 0 | 0 | - | - | |||
o = opacity
a = area
i = intensity
r = redness
s = swelling
- = not examined
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not considered irritating to the eye.
- Executive summary:
The irritant/corrosive potential of the test substance TCPP was studied on the eye of the rabbit in accordance with the OECD Guideline No. 405 for testing of Chemicals.
The results of this experiment indicate that the test substance is not irritating to the eye.
The substance does not have a significant local irritating potential to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
