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EC number: 609-567-4 | CAS number: 38661-72-2
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The mutagenic potential of 1,4-bis(isocyanatomethyl)cyclohexane was assessed in an Ames test, performed under GLP principles. The test item was tested in several strains of Salmonella typhimurium (TA98, TA100, TA1535 and TA1537) and in one strain of Escherichia coli (WP2uvrA) in the absence and in the presence of a metabolic activation system (S9 -mix). A dose-range finding study and two independent main studies were conducted. Concentrations up to and including 5000 µg/plate were used in the dose-range finding study. Based on the results of the dose-range finding study, the concentrations were determined for the main studies: the top dose was the minimum dose at which growth inhibition was observed in the dose-range finding study.
The test item precipitated on the plates at the top dose of 5000 μg/plate in the absence of S9 -mix and at a dose of 1250 µg/plate in the presence of S9 -mix. Cytotoxicity, as evidenced by a decrease in the number of revertants, was observed in all tester strains at different dose levels, with and without S9 -mix. In all strains, in the absence and in the presence of S9-mix, no increase in the number of revertants was observed. The results of the solvent control and the positive controls were within the historical range of the test facility.
In conclusion, 1,4 -bis(isocyanamethyl)cyclohexane is not mutagenic in the Salmonella typhimurium reverse mutation assay and in the Escherichia coli reverse mutation assay, with and without metabolic activation.
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