Registration Dossier
Registration Dossier
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EC number: 609-567-4 | CAS number: 38661-72-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Theoretical assessment taking all currrently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.
- Justification for type of information:
- The rationale to read across the data is attached in section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Theoretical assessment taking all currrently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.
- GLP compliance:
- no
- Type:
- absorption
- Results:
- For risk assessment purposes, 100% is used for oral, dermal and inhalation absorption
- Conclusions:
- A toxicokinetic assessment was performed based on the available data of 1,4-H6XDI. Based on the physical/chemical properties of 1,4-H6XDI, absorption factors are derived to be 100% (oral, inhalation and dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low.
Data source
Materials and methods
Test material
- Reference substance name:
- 1,3-bis(isocyanatomethyl)cyclohexane
- EC Number:
- 609-567-4
- Cas Number:
- 38661-72-2
- Molecular formula:
- C10 H14 N2 O2
- IUPAC Name:
- 1,3-bis(isocyanatomethyl)cyclohexane
- Test material form:
- liquid
Constituent 1
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- For risk assessment purposes, 100% is used for oral, dermal and inhalation absorption
Applicant's summary and conclusion
- Conclusions:
- A toxicokinetic assessment was performed based on the available data of 1,4-H6XDI. Based on the physical/chemical properties of 1,4-H6XDI, absorption factors are derived to be 100% (oral, inhalation and dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low. These conclusions are read across to 1,3-H6XDI.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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