Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
other: secondary literature
Title:
NITE - Chemical Management Field - GHS Information GHS Classification Result
Year:
2011
Bibliographic source:
GHS-J [Internet]. National Institute of Technology and Evaluation (NITE): GHS Classification Results by the Japanese Government. Available from: http://www.echemportal.org

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
not specified
Test type:
other: not specified

Test material

Specific details on test material used for the study:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Remarks on duration:
not specified
Concentrations:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
0.955 mg/L air
Exp. duration:
4 h
Mortality:
not observed
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Any other information on results incl. tables

not specified

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Besides, the s aturated vapour pressure concentration (0.722 mg/L) (converted to a 4-hour equivalent: 0.955 mg/L) exposure to rats for 7 hours resulted in no deaths, but the category could not be determined only from this data